InnateDB Protein
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IDBP-401310.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Lsg1
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Protein Name
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large subunit GTPase 1 homolog (S. cerevisiae)
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000112860
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InnateDB Gene
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IDBG-152479 (Lsg1)
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Protein Structure
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Function |
GTPase required for the XPO1/CRM1-mediated nuclear export of the 60S ribosomal subunit. Probably acts by mediating the release of NMD3 from the 60S ribosomal subunit after export into the cytoplasm (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}. Note=Shuttles between the Cajal bodies in the nucleus and the endoplasmic reticulum. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
0
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
4 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:107236
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InterPro |
IPR006073
GTP binding domain
IPR027417
P-loop containing nucleoside triphosphate hydrolase
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PFAM |
PF01926
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PRINTS |
PR00326
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q3UM18
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PhosphoSite |
PhosphoSite-Q3UM18
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
224092
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UniGene |
Mm.567
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RefSeq |
NP_835170
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MGI ID |
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MGI Symbol |
Lsg1
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OMIM |
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CCDS |
CCDS37311
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HPRD |
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IMGT |
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EMBL |
AK135345
AK145186
AK146895
BC043724
BC080306
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GenPept |
AAH43724
AAH80306
BAE22495
BAE26280
BAE27512
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