Version 5.4
Mus musculus Protein: Afap1l1
Summary
InnateDB Protein IDBP-401350.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Afap1l1
Protein Name actin filament associated protein 1-like 1
Synonyms AI173486;
Species Mus musculus
Ensembl Protein ENSMUSP00000113286
InnateDB Gene IDBG-152295 (Afap1l1)
Protein Structure
UniProt Annotation
Function May be involved in podosome and invadosome formation. {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Cell projection, podosome {ECO:0000250}. Cell projection, invadopodium {ECO:0000250}. Note=In the cytosol, associated with actin stress fibers. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0008150 biological_process
Cellular Component
GO:0002102 podosome
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0030054 cell junction
GO:0071437 invadopodium
Protein Structure and Domains
PDB ID MGI:2147199
InterPro IPR001849 Pleckstrin homology domain
PFAM PF00169
PRINTS
PIRSF
SMART SM00233
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BZI0
PhosphoSite PhosphoSite-Q8BZI0
TrEMBL B2RSM5
UniProt Splice Variant
Entrez Gene 106877
UniGene Mm.26632
RefSeq NP_849259
MGI ID
MGI Symbol Afap1l1
OMIM
CCDS CCDS50303
HPRD
IMGT
EMBL AK035227 AK053714 BC138923 CH466528
GenPept AAI38924 BAC28988 BAC35486 EDL09758

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca