Version 5.4
Mus musculus Protein: Sgcz
Summary
InnateDB Protein IDBP-401411.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sgcz
Protein Name sarcoglycan zeta
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000113912
InnateDB Gene IDBG-149455 (Sgcz)
Protein Structure
UniProt Annotation
Function Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. May play a role in the maintenance of striated muscle membrane stability.
Subcellular Localization Cell membrane, sarcolemma {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in the heart, skeletal muscle and arterial vascular smooth muscle.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0061024 membrane organization
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0016012 sarcoglycan complex
GO:0016021 integral component of membrane
GO:0042383 sarcolemma
Protein Structure and Domains
PDB ID MGI:2388820
InterPro IPR006875 Sarcoglycan complex subunit protein
PFAM PF04790
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BX51
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 244431
UniGene
RefSeq NP_665840
MGI ID
MGI Symbol Sgcz
OMIM
CCDS CCDS22251
HPRD
IMGT
EMBL AK048960 AK136779 AY095374 AY250713
GenPept AAM23275 AAP76378 BAC33500 BAE23127

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca