Version 5.4
Mus musculus Protein: Hira
Summary
InnateDB Protein IDBP-401496.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hira
Protein Name histone cell cycle regulation defective homolog A (S. cerevisiae)
Synonyms AA138857; D16Ertd95e; Gm15797; N28177; OTTMUSG00000026264; Tuple1;
Species Mus musculus
Ensembl Protein ENSMUSP00000112614
InnateDB Gene IDBG-142685 (Hira)
Protein Structure
UniProt Annotation
Function Required for the periodic repression of histone gene transcription during the cell cycle (By similarity). Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit. {ECO:0000250, ECO:0000269PubMed:16399082}.
Subcellular Localization Nucleus {ECO:0000250}. Nucleus, PML body {ECO:0000250}. Note=Primarily, though not exclusively, localized to the nucleus (By similarity). Localizes to PML bodies immediately prior to onset of senescence (By similarity). Localizes specifically to the male nucleus in fertilized eggs. This localization persists from the initiation of sperm nucleus decondensation to pronucleus formation. {ECO:0000250, ECO:0000269PubMed:15922569, ECO:0000269PubMed:9731536}.
Disease Associations
Tissue Specificity Expressed in cerebrum, cerebellum, heart, kidney, liver, lung and spleen.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 15 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003682 chromatin binding
GO:0005515 protein binding
Biological Process
GO:0001649 osteoblast differentiation
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007369 gastrulation
GO:0016568 chromatin modification
GO:0042692 muscle cell differentiation
Cellular Component
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0016605 PML body
Protein Structure and Domains
PDB ID MGI:99430
InterPro IPR001680 WD40 repeat
IPR017986 WD40-repeat-containing domain
IPR019015 HIRA B motif
PFAM PF00400
PF09453
PRINTS
PIRSF
SMART SM00320
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q61666
PhosphoSite PhosphoSite-Q61666
TrEMBL
UniProt Splice Variant
Entrez Gene 15260
UniGene Mm.15694
RefSeq
MGI ID
MGI Symbol Hira
OMIM
CCDS
HPRD
IMGT
EMBL AK135928 AK168963 BC052856 X75295 X92590 X99712
GenPept AAH52856 BAE22728 BAE40768 CAA53043 CAA63334 CAA68049

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca