Homo sapiens Protein: SMARCC2 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Protein | IDBP-40156.7 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | SMARCC2 | ||||||||||||||||||||||
Protein Name | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 | ||||||||||||||||||||||
Synonyms | BAF170; CRACC2; Rsc8; | ||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Protein | ENSP00000302919 | ||||||||||||||||||||||
InnateDB Gene | IDBG-40152 (SMARCC2) | ||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||
Function | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Can stimulate the ATPase activity of the catalytic subunit of these complexes. May be required for CoREST dependent repression of neuronal specific gene promoters in non-neuronal cells. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250}. | ||||||||||||||||||||||
Subcellular Localization | Nucleus. | ||||||||||||||||||||||
Disease Associations | |||||||||||||||||||||||
Tissue Specificity | Ubiquitously expressed. | ||||||||||||||||||||||
Comments | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 127 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||||||
PDB ID | |||||||||||||||||||||||
InterPro |
IPR000953
Chromo domain/shadow IPR001005 SANT/Myb domain IPR001357 BRCT domain IPR007526 SWIRM domain IPR009057 Homeodomain-like IPR016197 Chromo domain-like IPR017877 Myb-like domain |
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PFAM |
PF00249
PF00533 PF12738 PF04433 |
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PRINTS | |||||||||||||||||||||||
PIRSF | |||||||||||||||||||||||
SMART |
SM00298
SM00717 SM00292 |
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TIGRFAMs | |||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||
Modification | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | Q8TAQ2 | ||||||||||||||||||||||
PhosphoSite | PhosphoSite-Q8TAQ2 | ||||||||||||||||||||||
TrEMBL | F8VZW6 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 6601 | ||||||||||||||||||||||
UniGene | Hs.733233 | ||||||||||||||||||||||
RefSeq | NP_620706 | ||||||||||||||||||||||
HUGO | HGNC:11105 | ||||||||||||||||||||||
OMIM | 601734 | ||||||||||||||||||||||
CCDS | CCDS8908 | ||||||||||||||||||||||
HPRD | 03437 | ||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AB209006 AC073896 BC009067 BC013045 BC026222 BT009924 U66616 | ||||||||||||||||||||||
GenPept | AAC50694 AAH09067 AAH13045 AAH26222 AAP88926 BAD92243 | ||||||||||||||||||||||