Mus musculus Protein: Dnase1l2 | |||||||||
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Summary | |||||||||
InnateDB Protein | IDBP-401568.4 | ||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
Gene Symbol | Dnase1l2 | ||||||||
Protein Name | deoxyribonuclease 1-like 2 | ||||||||
Synonyms | 4733401H14Rik; | ||||||||
Species | Mus musculus | ||||||||
Ensembl Protein | ENSMUSP00000113508 | ||||||||
InnateDB Gene | IDBG-146562 (Dnase1l2) | ||||||||
Protein Structure | |||||||||
UniProt Annotation | |||||||||
Function | Divalent cation-dependent acid DNA endonuclease involved in the breakdown of the nucleus during corneocyte formation of epidermal keratinocytes. May play an immune role by eliminating harmful DNA released into the extracellular environment by damaged epidermal cells (By similarity). {ECO:0000250}. | ||||||||
Subcellular Localization | Cytoplasm {ECO:0000250}. Secreted {ECO:0000305}. | ||||||||
Disease Associations | |||||||||
Tissue Specificity | |||||||||
Comments | |||||||||
Interactions | |||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||
PDB ID | MGI:1913955 | ||||||||
InterPro |
IPR005135
Endonuclease/exonuclease/phosphatase IPR016202 Deoxyribonuclease I |
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PFAM |
PF03372
PF14529 |
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PRINTS |
PR00130
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PIRSF |
PIRSF000988
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SMART |
SM00476
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TIGRFAMs | |||||||||
Post-translational Modifications | |||||||||
Modification | |||||||||
Cross-References | |||||||||
SwissProt | Q9D1G0 | ||||||||
PhosphoSite | PhosphoSite-Q9D1G0 | ||||||||
TrEMBL | D3Z3Z7 | ||||||||
UniProt Splice Variant | |||||||||
Entrez Gene | 66705 | ||||||||
UniGene | |||||||||
RefSeq | XP_006524862 | ||||||||
MGI ID | |||||||||
MGI Symbol | Dnase1l2 | ||||||||
OMIM | |||||||||
CCDS | CCDS37489 | ||||||||
HPRD | |||||||||
IMGT | |||||||||
EMBL | AC154237 AK003619 AK014633 BC106188 | ||||||||
GenPept | AAI06189 BAB22893 BAB29476 | ||||||||