Version 5.4
Mus musculus Protein: Trib1
Summary
InnateDB Protein IDBP-401571.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Trib1
Protein Name tribbles homolog 1 (Drosophila)
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000112828
InnateDB Gene IDBG-144324 (Trib1)
Protein Structure
UniProt Annotation
Function Interacts with MAPK kinases and regulates activation of MAP kinases. May not display kinase activity (By similarity). {ECO:0000250UniProtKB:Q96RU8}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004860 protein kinase inhibitor activity
GO:0005524 ATP binding
GO:0008134 transcription factor binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0031434 mitogen-activated protein kinase kinase binding
GO:0031625 ubiquitin protein ligase binding
GO:0055106 ubiquitin-protein ligase regulator activity
Biological Process
GO:0006468 protein phosphorylation
GO:0006469 negative regulation of protein kinase activity
GO:0007254 JNK cascade
GO:0014912 negative regulation of smooth muscle cell migration
GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032496 response to lipopolysaccharide
GO:0043405 regulation of MAP kinase activity
GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity
GO:0048662 negative regulation of smooth muscle cell proliferation
GO:0051443 positive regulation of ubiquitin-protein transferase activity
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:2443397
InterPro IPR000719 Protein kinase domain
IPR011009 Protein kinase-like domain
PFAM PF00069
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8K4K4
PhosphoSite PhosphoSite-Q8K4K4
TrEMBL
UniProt Splice Variant
Entrez Gene 211770
UniGene Mm.40298
RefSeq
MGI ID
MGI Symbol Trib1
OMIM
CCDS
HPRD
IMGT
EMBL AF358866 AK028626 AK033358 AK040738 AK041212 AK080228 AK162876 BC006800
GenPept AAH06800 AAM45478 BAC26038 BAC28245 BAC30688 BAC30865 BAC37854 BAE37097

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca