InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PSMD11

Summary

InnateDB Protein

IDBP-40159.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PSMD11

Protein Name

proteasome (prosome, macropain) 26S subunit, non-ATPase, 11

Synonyms

p44.5; Rpn6; S9;

Species

Homo sapiens

Ensembl Protein

ENSP00000261712

InnateDB Gene

IDBG-40157 (PSMD11)

Protein Structure

UniProt Annotation

Function

Component of the lid subcomplex of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. In the complex, PSMD11 is required for proteasome assembly. Plays a key role in increased proteasome activity in embryonic stem cells (ESCs): its high expression in ESCs promotes enhanced assembly of the 26S proteasome, followed by higher proteasome activity. {ECO:0000269PubMed:22972301}.

Subcellular Localization

Nucleus {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in embryonic stem cells (ESCs). Expression decreases as ESCs differentiate. {ECO:0000269PubMed:22972301}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 127 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	127 [view]
Protein-Protein	127 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0000209	protein polyubiquitination
GO:0000278	mitotic cell cycle
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0006521	regulation of cellular amino acid metabolic process
GO:0006915	apoptotic process
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0010467	gene expression
GO:0016032	viral process
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0034641	cellular nitrogen compound metabolic process
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0042981	regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0043248	proteasome assembly
GO:0044281	small molecule metabolic process
GO:0048863	stem cell differentiation
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle

Cellular Component

GO:0000502	proteasome complex
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005829	cytosol
GO:0005838	proteasome regulatory particle
GO:0016020	membrane
GO:0022624	proteasome accessory complex
GO:0070062	extracellular vesicular exosome