InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: S1pr5

Summary

InnateDB Protein

IDBP-401605.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

S1pr5

Protein Name

sphingosine-1-phosphate receptor 5

Synonyms

Edg8; lpB4; S1P5;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000113843

InnateDB Gene

IDBG-139595 (S1pr5)

Protein Structure

UniProt Annotation

Function

Receptor for the lysosphingolipid sphingosine 1- phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Is coupled to both the G(i/0)alpha and G(12) subclass of heteromeric G-proteins (By similarity). S1P activation on oligodendroglial cells modulates two distinct functional pathways mediating either process retraction or cell survival. S1P activation on O4-positive pre-oligodendrocytes induces process retraction via a Rho kinase/collapsin response-mediated protein signaling pathway. The S1P-induced survival of mature oligodendrocytes is mediated through a pertussis toxin-sensitive, Akt-dependent pathway. S1P activation on oligodendroglial cells modulates two distinct functional pathways mediating either process retraction or cell survival. These effects depend on the developmental stage of the cell. {ECO:0000250, ECO:0000269PubMed:15703400}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Expressed in spleen and brain. In the CNS expression is restricted to oligodendrocytes. {ECO:0000269PubMed:11705398, ECO:0000269PubMed:15703400}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0038036	sphingosine-1-phosphate receptor activity

Biological Process

GO:0003376	sphingosine-1-phosphate signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0045664	regulation of neuron differentiation

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:2150641

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR002230 Cannabinoid receptor family
IPR004061 Sphingosine 1-phosphate receptor
IPR005386 EDG-8 sphingosine 1-phosphate receptor
IPR017452 GPCR, rhodopsin-like, 7TM

PFAM

PF00001

PRINTS

PR00237
PR00362
PR01523
PR01561

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q91X56