Version 5.4
Mus musculus Protein: Map3k5
Summary
InnateDB Protein IDBP-401635.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Map3k5
Protein Name mitogen-activated protein kinase kinase kinase 5
Synonyms 7420452D20Rik; ASK; ASK1; MAPKKK5; Mekk5;
Species Mus musculus
Ensembl Protein ENSMUSP00000112864
InnateDB Gene IDBG-136255 (Map3k5)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 91 interaction(s) predicted by orthology.
Experimentally validated
Total 20 [view]
Protein-Protein 19 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 91 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004709 MAP kinase kinase kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0019903 protein phosphatase binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0000186 activation of MAPKK activity
GO:0000187 activation of MAPK activity
GO:0002931 response to ischemia
GO:0006468 protein phosphorylation
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007254 JNK cascade
GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0010941 regulation of cell death
GO:0045087 innate immune response (InnateDB)
GO:0070301 cellular response to hydrogen peroxide
GO:0097300 programmed necrotic cell death
GO:1902170 cellular response to reactive nitrogen species
Cellular Component
Protein Structure and Domains
PDB ID MGI:1346876
InterPro IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR013761 Sterile alpha motif/pointed domain
IPR020635 Tyrosine-protein kinase, catalytic domain
PFAM PF00069
PF07714
PRINTS PR00109
PIRSF
SMART SM00220
SM00219
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q8CC79
UniProt Splice Variant
Entrez Gene 26408
UniGene Mm.6595
RefSeq
MGI ID
MGI Symbol Map3k5
OMIM
CCDS
HPRD
IMGT
EMBL AC158620 AC158621 AC168883 AC171277 AK033726
GenPept BAC28449

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca