InnateDB Protein
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IDBP-401654.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Ube2w
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Protein Name
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ubiquitin-conjugating enzyme E2W (putative)
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Synonyms
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6130401J04Rik;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000112741
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InnateDB Gene
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IDBG-135309 (Ube2w)
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Protein Structure
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Function |
Transfers ubiquitin in complex with RING/U-box type E3s that do not have active site cysteine residues to form thioester bonds with ubiquitin, and preferentially ubiquitinates the N- terminus of substrates, such as ATXN3, STUB1 and SUMO2 (By similarity). Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in degradation of misfolded chaperone substrates by mediating monoubiquitination of STUB1/CHIP, leading to recruitment of ATXN3 to monoubiquitinated STUB1/CHIP, and restriction of the length of ubiquitin chain attached to STUB1/CHIP substrates by ATXN3. After UV irradiation, but not after mitomycin-C (MMC) treatment, acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway. In vitro catalyzes 'Lys-11'-linked polyubiquitination. {ECO:0000250, ECO:0000269PubMed:21229326, ECO:0000269PubMed:21855799}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:21229326}. Note=In the nucleus, colocalizes with FANCL.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0006281
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DNA repair
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GO:0006513
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protein monoubiquitination
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GO:0006515
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misfolded or incompletely synthesized protein catabolic process
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GO:0043161
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proteasome-mediated ubiquitin-dependent protein catabolic process
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GO:0070979
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protein K11-linked ubiquitination
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GO:0071218
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cellular response to misfolded protein
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Cellular Component |
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PDB ID |
MGI:1914049
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InterPro |
IPR000608
Ubiquitin-conjugating enzyme, E2
IPR016135
Ubiquitin-conjugating enzyme/RWD-like
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PFAM |
PF00179
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8VDW4
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
66799
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UniGene |
Mm.473851
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RefSeq |
NP_080049
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MGI ID |
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MGI Symbol |
Ube2w
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OMIM |
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CCDS |
CCDS48224
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HPRD |
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IMGT |
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EMBL |
AK015348
AK044463
AK046086
AK050679
AK077997
AK082233
BC020124
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GenPept |
AAH20124
BAB29807
BAC31935
BAC32599
BAC34377
BAC37094
BAC38443
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