InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Atf7ip2

Summary

InnateDB Protein

IDBP-401699.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Atf7ip2

Protein Name

activating transcription factor 7 interacting protein 2

Synonyms

4930558K11Rik; BC018510; Get-1; PSM2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000113573

InnateDB Gene

IDBG-132060 (Atf7ip2)

Protein Structure

UniProt Annotation

Function

Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1. The complex formed with MBD1 and SETDB1 represses transcription and probably couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) activity (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in testis. {ECO:0000269PubMed:16850184}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0008150	biological_process

Cellular Component

GO:0005730	nucleolus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:1922579

InterPro

PFAM

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q3UL97

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

75329

UniGene

Mm.108729

RefSeq

XP_006519933

MGI ID

MGI Symbol

Atf7ip2

OMIM

CCDS

HPRD

IMGT

EMBL

AK016180 AK077229 AK139862 AK145634 AY903215

GenPept

AAX99226 BAB30138 BAC36698 BAE24164 BAE26553