InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Klhl14

Summary

InnateDB Protein

IDBP-401736.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Klhl14

Protein Name

kelch-like 14 (Drosophila)

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000113755

InnateDB Gene

IDBG-130703 (Klhl14)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Cytoplasm, cytosol {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}. Note=In neurons, located in cell bodies, as well as in neurites. {ECO:0000269PubMed:19535332}.

Disease Associations

Tissue Specificity

Expressed in the brain, primarily in neurons. In the cerebral cortex, mostly expressed in layers I and II (at protein level). Also observed in some neurons of the corpus striatum (at protein level). Expressed at high levels in the hippocampus, including in pyramidal cells of the CA1 and CA3 layers (at protein level). In the cerebellum, expression in Purkinje cells is higher than in granular cells (at protein level). Also detected in the medial septum, ventral pallidum, thalamus, hypothalamus, amygdala, inferior colliculi, locus caeruleus, peripyramidal nucleus, raphe nucleus, reticular formation, spinal trigeminal nucleus, and vestibular nuclei (at protein level). Low expression, if any, in glial cells (at protein level). Not observed in the corpus callosum. {ECO:0000269PubMed:19535332}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0008150

biological_process

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005829	cytosol
GO:0043005	neuron projection
GO:0043025	neuronal cell body

Protein Structure and Domains

PDB ID

MGI:1921249

InterPro

IPR000210 BTB/POZ-like
IPR006652 Kelch repeat type 1
IPR011333 BTB/POZ fold
IPR011705 BTB/Kelch-associated
IPR013069 BTB/POZ
IPR017096 Kelch-like protein, gigaxonin type

PFAM

PF01344
PF07707
PF00651

PRINTS

PIRSF

PIRSF037037

SMART

SM00225
SM00612
SM00875

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt