Version 5.4
Homo sapiens Protein: GZMH
Summary
InnateDB Protein IDBP-4026.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GZMH
Protein Name granzyme H (cathepsin G-like 2, protein h-CCPX)
Synonyms CCP-X; CGL-2; CSP-C; CTLA1; CTSGL2;
Species Homo sapiens
Ensembl Protein ENSP00000216338
InnateDB Gene IDBG-4020 (GZMH)
Protein Structure
UniProt Annotation
Function Cytotoxic chymotrypsin-like serine protease with preference for bulky and aromatic residues at the P1 position and acidic residues at the P3' and P4' sites. Probably necessary for target cell lysis in cell-mediated immune responses. Participates in the antiviral response via direct cleavage of several proteins essential for viral replication. {ECO:0000269PubMed:22156497, ECO:0000269PubMed:23269243}.
Subcellular Localization Cytoplasmic granule. Note=Cytoplasmic granules of cytolytic T-lymphocytes.
Disease Associations
Tissue Specificity Constituvely expressed in NK cells. {ECO:0000269PubMed:23269243}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis
GO:0006915 apoptotic process
GO:0019835 cytolysis
Cellular Component
GO:0016020 membrane
GO:0030141 secretory granule
Protein Structure and Domains
PDB ID
InterPro IPR001254 Peptidase S1
IPR001314 Peptidase S1A, chymotrypsin-type
IPR009003 Trypsin-like cysteine/serine peptidase domain
PFAM PF00089
PRINTS PR00722
PIRSF
SMART SM00020
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P20718
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 2999
UniGene Hs.348264
RefSeq NP_219491
HUGO HGNC:4710
OMIM 116831
CCDS CCDS9632
HPRD 00290
IMGT
EMBL AL136018 AY232657 AY232658 BC027974 CH471078 J02907 M36118 M57888 M72150
GenPept AAA03248 AAA03514 AAA74885 AAA76859 AAH27974 AAP70247 AAP70248 EAW66004

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca