InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RNF41

Summary

InnateDB Protein

IDBP-40315.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RNF41

Protein Name

ring finger protein 41

Synonyms

FLRF; NRDP1;

Species

Homo sapiens

Ensembl Protein

ENSP00000342755

InnateDB Gene

IDBG-40313 (RNF41)

Protein Structure

UniProt Annotation

Function

Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88 and Negatively regulates MYD88-dependent production of proinflammatory cytokines but can promote TRIF-dependent production of type I interferon. Promotes also activation of TBK1 and IRF3. Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL- 3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages (By similarity). Contributes to the maintenance of steady-state ERBB3 levels by mediating its growth factor-independent degradation. Involved in the degradation of the inhibitor of apoptosis BIRC6 and thus is an important regulator of cell death by promoting apoptosis. Acts also as a PARK2 modifier that accelerates its degradation, resulting in a reduction of PARK2 activity, influencing the balance of intracellular redox state. {ECO:0000250, ECO:0000269PubMed:12411582, ECO:0000269PubMed:14765125, ECO:0000269PubMed:15632191, ECO:0000269PubMed:17210635, ECO:0000269PubMed:18541373, ECO:0000269PubMed:19483718}.

Subcellular Localization

Disease Associations

Tissue Specificity

Detected in ovary, testis and prostate. {ECO:0000269PubMed:12411582}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 40 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Experimentally validated
Total	40 [view]
Protein-Protein	40 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005128	erythropoietin receptor binding
GO:0005135	interleukin-3 receptor binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016881	acid-amino acid ligase activity
GO:0031386	protein tag
GO:0046872	metal ion binding

Biological Process

GO:0000209	protein polyubiquitination
GO:0008285	negative regulation of cell proliferation
GO:0010468	regulation of gene expression
GO:0016567	protein ubiquitination
GO:0030336	negative regulation of cell migration
GO:0043408	regulation of MAPK cascade
GO:0045087	innate immune response (InnateDB)
GO:0045619	regulation of lymphocyte differentiation
GO:0045637	regulation of myeloid cell differentiation
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051865	protein autoubiquitination
GO:0051896	regulation of protein kinase B signaling
GO:0097191	extrinsic apoptotic signaling pathway
GO:2000114	regulation of establishment of cell polarity
GO:2000377	regulation of reactive oxygen species metabolic process

Cellular Component

GO:0005829

cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR001841 Zinc finger, RING-type
IPR003613 U box domain
IPR008974 TRAF-like
IPR013010 Zinc finger, SIAH-type
IPR015036 USP8 interacting
IPR018957 Zinc finger, C3HC4 RING-type

PFAM

PF13639
PF14634
PF04564
PF08941
PF00097

PRINTS

PIRSF

SMART

SM00184
SM00504

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9H4P4