InnateDB Protein
|
IDBP-40408.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
NABP2
|
Protein Name
|
oligonucleotide/oligosaccharide-binding fold containing 2B
|
Synonyms
|
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000267023
|
InnateDB Gene
|
IDBG-40406 (NABP2)
|
Protein Structure
|
|
Function |
Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. {ECO:0000269PubMed:18449195, ECO:0000269PubMed:19605351, ECO:0000269PubMed:19683501}.
|
Subcellular Localization |
Nucleus {ECO:0000269PubMed:18449195, ECO:0000269PubMed:19605351, ECO:0000269PubMed:19683501}. Note=Localizes to nuclear foci following DNA damage. Foci formation is not cell-cycle dependent. Partial colocalization with RAD51 after ionizing radiation treatment.
|
Disease Associations |
|
Tissue Specificity |
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
30
[view]
|
Protein-Protein |
30
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
1 [view]
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR004365
OB-fold nucleic acid binding domain, AA-tRNA synthetase-type
IPR012340
Nucleic acid-binding, OB-fold
|
PFAM |
PF01336
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q9BQ15
|
PhosphoSite |
PhosphoSite-Q9BQ15
|
TrEMBL |
C9JT95
|
UniProt Splice Variant |
|
Entrez Gene |
79035
|
UniGene |
|
RefSeq |
NP_076973
|
HUGO |
HGNC:28412
|
OMIM |
612104
|
CCDS |
CCDS8911
|
HPRD |
14522
|
IMGT |
|
EMBL |
AC073896
AY203942
BC001079
BC006171
CH471054
|
GenPept |
AAH01079
AAH06171
AAP34465
EAW96913
EAW96915
|
|
|