Version 5.4
Homo sapiens Protein: NABP2
Summary
InnateDB Protein IDBP-40410.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NABP2
Protein Name oligonucleotide/oligosaccharide-binding fold containing 2B
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000368862
InnateDB Gene IDBG-40406 (NABP2)
Protein Structure
UniProt Annotation
Function Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. {ECO:0000269PubMed:18449195, ECO:0000269PubMed:19605351, ECO:0000269PubMed:19683501}.
Subcellular Localization Nucleus {ECO:0000269PubMed:18449195, ECO:0000269PubMed:19605351, ECO:0000269PubMed:19683501}. Note=Localizes to nuclear foci following DNA damage. Foci formation is not cell-cycle dependent. Partial colocalization with RAD51 after ionizing radiation treatment.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 30 [view]
Protein-Protein 30 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003697 single-stranded DNA binding
GO:0005515 protein binding
Biological Process
GO:0000724 double-strand break repair via homologous recombination
GO:0006281 DNA repair
GO:0006974 cellular response to DNA damage stimulus
GO:0007093 mitotic cell cycle checkpoint
GO:0010212 response to ionizing radiation
Cellular Component
GO:0005634 nucleus
GO:0070876 SOSS complex
Protein Structure and Domains
PDB ID
InterPro IPR004365 OB-fold nucleic acid binding domain, AA-tRNA synthetase-type
IPR012340 Nucleic acid-binding, OB-fold
PFAM PF01336
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BQ15
PhosphoSite PhosphoSite-Q9BQ15
TrEMBL C9JT95
UniProt Splice Variant
Entrez Gene 79035
UniGene
RefSeq XP_005269204
HUGO HGNC:28412
OMIM 612104
CCDS CCDS8911
HPRD 14522
IMGT
EMBL AC073896 AY203942 BC001079 BC006171 CH471054
GenPept AAH01079 AAH06171 AAP34465 EAW96913 EAW96915

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca