InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CDC42SE2

Summary

InnateDB Protein

IDBP-40425.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CDC42SE2

Protein Name

CDC42 small effector 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000353706

InnateDB Gene

IDBG-40423 (CDC42SE2)

Protein Structure

UniProt Annotation

Function

Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages. {ECO:0000269PubMed:10816584, ECO:0000269PubMed:15840583}.

Subcellular Localization

Cytoplasm, cytoskeleton. Cell membrane; Lipid-anchor. Cell projection, phagocytic cup. Note=Recruited to the activated TCR prior actin polymerization. Localizes at the phagocytic cup of macrophages.

Disease Associations

Tissue Specificity

Widely expressed. Expressed at higher level in T-lymphocytes. Highly expressed in CCRF-CEM T-lymphocytes, Jurkat T-lymphocytes, and Raji B-lymphocytes compared (at protein level). {ECO:0000269PubMed:15840583}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005198	structural molecule activity
GO:0005515	protein binding

Biological Process

GO:0006909	phagocytosis
GO:0008360	regulation of cell shape
GO:0009966	regulation of signal transduction

Cellular Component

GO:0001891	phagocytic cup
GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0042995	cell projection
GO:0070062	extracellular vesicular exosome