InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RAPGEF6

Summary

InnateDB Protein

IDBP-40472.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RAPGEF6

Protein Name

Rap guanine nucleotide exchange factor (GEF) 6

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000309298

InnateDB Gene

IDBG-40464 (RAPGEF6)

Protein Structure

UniProt Annotation

Function

Guanine nucleotide exchange factor (GEF) for Rap1A, Rap2A and M-Ras GTPases. Does not interact with cAMP. {ECO:0000269PubMed:11524421, ECO:0000269PubMed:12581858}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:11524421}. Cell membrane {ECO:0000269PubMed:11524421}. Note=Upon binding to M-Ras, it translocates to the plasma membrane.

Disease Associations

Tissue Specificity

Isoform 3 has highest expression levels in the brain, heart, liver, lung and placenta and is barely detectable in skeletal muscle, kidney and pancreas. {ECO:0000269PubMed:11524421}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.

Experimentally validated
Total	12 [view]
Protein-Protein	10 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005515	protein binding
GO:0017016	Ras GTPase binding
GO:0030742	GTP-dependent protein binding

Biological Process

GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0007265	Ras protein signal transduction
GO:0043087	regulation of GTPase activity
GO:0043547	positive regulation of GTPase activity
GO:0051056	regulation of small GTPase mediated signal transduction

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005886	plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000159 Ras-association
IPR000595 Cyclic nucleotide-binding domain
IPR000651 Ras-like guanine nucleotide exchange factor, N-terminal
IPR001478 PDZ domain
IPR001895 Ras guanine-nucleotide exchange factors catalytic domain
IPR018490 Cyclic nucleotide-binding-like
IPR023578 Ras guanine nucleotide exchange factor domain
IPR029071 Ubiquitin-related domain

PFAM

PF00788
PF00027
PF00618
PF00595
PF13180
PF00617

PRINTS

PIRSF

SMART

SM00314
SM00100
SM00229
SM00228
SM00147

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8TEU7