InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: VAC14

Summary

InnateDB Protein

IDBP-40483.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

VAC14

Protein Name

Vac14 homolog (S. cerevisiae)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000261776

InnateDB Gene

IDBG-40481 (VAC14)

Protein Structure

UniProt Annotation

Function

The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts as a positive activator of PIKfyve kinase activity. Also required to maintain normal levels of phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 5-phosphate (PtdIns(5)P). Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes. {ECO:0000269PubMed:15542851, ECO:0000269PubMed:17556371}.

Subcellular Localization

Endosome membrane {ECO:0000269PubMed:15542851, ECO:0000269PubMed:17556371}. Microsome membrane {ECO:0000250}. Note=Mainly associated with membranes of the late endocytic pathway.

Disease Associations

Tissue Specificity

Ubiquitously expressed. {ECO:0000269PubMed:8611628}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.

Experimentally validated
Total	15 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005488	binding
GO:0005515	protein binding

Biological Process

GO:0006644	phospholipid metabolic process
GO:0006661	phosphatidylinositol biosynthetic process
GO:0007165	signal transduction
GO:0016032	viral process
GO:0043550	regulation of lipid kinase activity
GO:0044281	small molecule metabolic process

Cellular Component

GO:0000139	Golgi membrane
GO:0005783	endoplasmic reticulum
GO:0010008	endosome membrane
GO:0031901	early endosome membrane
GO:0031902	late endosome membrane
GO:0070772	PAS complex