InnateDB Protein
|
IDBP-40590.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
DGAT1
|
Protein Name
|
diacylglycerol O-acyltransferase 1
|
Synonyms
|
ARAT; ARGP1; DGAT; DIAR7;
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000332258
|
InnateDB Gene
|
IDBG-40588 (DGAT1)
|
Protein Structure
|
|
Function |
Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. In contrast to DGAT2 it is not essential for survival. May be involved in VLDL (very low density lipoprotein) assembly. In liver, plays a role in esterifying exogenous fatty acids to glycerol. Functions as the major acyl-CoA retinol acyltransferase (ARAT) in the skin, where it acts to maintain retinoid homeostasis and prevent retinoid toxicity leading to skin and hair disorders.
|
Subcellular Localization |
Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
|
Disease Associations |
|
Tissue Specificity |
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
6
[view]
|
Protein-Protein |
6
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
|
|
Molecular Function |
Accession |
GO Term |
GO:0004144
|
diacylglycerol O-acyltransferase activity
|
GO:0005515
|
protein binding
|
GO:0016746
|
transferase activity, transferring acyl groups
|
GO:0016772
|
transferase activity, transferring phosphorus-containing groups
|
GO:0050252
|
retinol O-fatty-acyltransferase activity
|
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR008279
PEP-utilising enzyme, mobile domain
|
PFAM |
PF00391
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
O75907
|
PhosphoSite |
PhosphoSite-O75907
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
8694
|
UniGene |
Hs.521954
|
RefSeq |
|
HUGO |
HGNC:2843
|
OMIM |
604900
|
CCDS |
|
HPRD |
05360
|
IMGT |
|
EMBL |
AB057815
AF059202
BC015762
BC023565
BC150649
CH471162
|
GenPept |
AAC63997
AAH15762
AAH23565
AAI50650
BAC66170
EAW82127
EAW82129
|
|
|