InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CCL13

Summary

InnateDB Protein

IDBP-40709.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CCL13

Protein Name

chemokine (C-C motif) ligand 13

Synonyms

CKb10; MCP-4; NCC-1; NCC1; SCYA13; SCYL1;

Species

Homo sapiens

Ensembl Protein

ENSP00000225844

InnateDB Gene

IDBG-40707 (CCL13)

Protein Structure

UniProt Annotation

Function

Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. Signals through CCR2B and CCR3 receptors. Plays a role in the accumulation of leukocytes at both sides of allergic and non-allergic inflammation. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. May play a role in the monocyte attraction in tissues chronically exposed to exogenous pathogens.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Widely expressed. Found in small intestine, thymus, colon, lung, trachea, stomach and lymph node. Low levels seen in the pulmonary artery smooth muscle cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.

Experimentally validated
Total	13 [view]
Protein-Protein	11 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0008009	chemokine activity

Biological Process

GO:0006874	cellular calcium ion homeostasis
GO:0006935	chemotaxis
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0007010	cytoskeleton organization
GO:0007165	signal transduction
GO:0007267	cell-cell signaling
GO:0008360	regulation of cell shape
GO:0048245	eosinophil chemotaxis