InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DCLK2

Summary

InnateDB Protein

IDBP-40728.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DCLK2

Protein Name

doublecortin-like kinase 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000303887

InnateDB Gene

IDBG-40724 (DCLK2)

Protein Structure

UniProt Annotation

Function

Protein kinase with a significantly reduced C(a2+)/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytoskeleton. Note=Colocalizes with microtubules. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in the brain, heart and eyes. {ECO:0000269PubMed:18075264}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0035556	intracellular signal transduction

Cellular Component

GO:0005737	cytoplasm
GO:0005856	cytoskeleton

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR003533 Doublecortin domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714
PF03607

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00537
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt