Version 5.4
Homo sapiens Protein: IL23A
Summary
InnateDB Protein IDBP-40893.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL23A
Protein Name interleukin 23, alpha subunit p19
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000228534
InnateDB Gene IDBG-40891 (IL23A)
Protein Structure
UniProt Annotation
Function Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak- Stat signaling cascade, stimulates memory rather than naive T- cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis. {ECO:0000269PubMed:11114383, ECO:0000269PubMed:12023369, ECO:0000269PubMed:16424222}.
Subcellular Localization Secreted {ECO:0000269PubMed:11114383}. Note=Secreted upon association with IL12B.
Disease Associations
Tissue Specificity Secreted by activated dendritic and phagocytic cells and keratinocytes. Also expressed by dermal Langerhans cells (at protein level). {ECO:0000269PubMed:11114383, ECO:0000269PubMed:16424222}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 9 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005515 protein binding
GO:0045519 interleukin-23 receptor binding
Biological Process
GO:0001916 positive regulation of T cell mediated cytotoxicity
GO:0002230 positive regulation of defense response to virus by host
GO:0002827 positive regulation of T-helper 1 type immune response
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0010535 positive regulation of activation of JAK2 kinase activity
GO:0032693 negative regulation of interleukin-10 production
GO:0032725 positive regulation of granulocyte macrophage colony-stimulating factor production
GO:0032729 positive regulation of interferon-gamma production
GO:0032733 positive regulation of interleukin-10 production
GO:0032735 positive regulation of interleukin-12 production
GO:0032740 positive regulation of interleukin-17 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0032816 positive regulation of natural killer cell activation
GO:0032819 positive regulation of natural killer cell proliferation
GO:0034105 positive regulation of tissue remodeling
GO:0042098 T cell proliferation
GO:0042102 positive regulation of T cell proliferation
GO:0042104 positive regulation of activated T cell proliferation
GO:0042346 positive regulation of NF-kappaB import into nucleus
GO:0042510 regulation of tyrosine phosphorylation of Stat1 protein
GO:0042517 positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0042520 positive regulation of tyrosine phosphorylation of Stat4 protein
GO:0042523 positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0043382 positive regulation of memory T cell differentiation
GO:0045087 innate immune response (InnateDB)
GO:0045672 positive regulation of osteoclast differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048771 tissue remodeling
GO:0050729 positive regulation of inflammatory response
GO:0050829 defense response to Gram-negative bacterium
GO:0051135 positive regulation of NK T cell activation
GO:0051142 positive regulation of NK T cell proliferation
GO:0051607 defense response to virus
GO:0090023 positive regulation of neutrophil chemotaxis
GO:2000318 positive regulation of T-helper 17 type immune response
GO:2000330 positive regulation of T-helper 17 cell lineage commitment
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0070743 interleukin-23 complex
Protein Structure and Domains
PDB ID
InterPro IPR003573 Interleukin-6/Interleukin-23/GCSF/MGF
IPR009079 Four-helical cytokine-like, core
PFAM PF00489
PRINTS PR00433
PIRSF PIRSF001935
SMART SM00126
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NPF7
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 51561
UniGene Hs.98309
RefSeq NP_057668
HUGO HGNC:15488
OMIM 605580
CCDS CCDS8916
HPRD 12026
IMGT
EMBL AB030000 AB030001 AF301620 AY359083 BC066267 BC066268 BC066269 BC067511 BC067512 BC067513
GenPept AAG37232 AAH66267 AAH66268 AAH66269 AAH67511 AAH67512 AAH67513 AAQ89442 BAA93686 BAA93687

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca