InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ZC3HC1

Summary

InnateDB Protein

IDBP-40973.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ZC3HC1

Protein Name

zinc finger, C3HC-type containing 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000351052

InnateDB Gene

IDBG-40971 (ZC3HC1)

Protein Structure

UniProt Annotation

Function

Essential component of an SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1). Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting CCNB1 ubiquitination activity to interphase. Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry. May have an antiapoptotic role in NPM-ALK-mediated signaling events. {ECO:0000269PubMed:16009132}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:12748172}.

Disease Associations

Tissue Specificity

Widely expressed. Highly expressed in heart, skeletal muscle and testis. Expressed in brain, placenta, lung, kidney, liver, pancreas, spleen, thymus, prostate, ovary small intestine and colon. Weakly or not expressed in leukocytes. {ECO:0000269PubMed:12748172}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	28 [view]
Protein-Protein	28 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0019901	protein kinase binding

Biological Process

GO:0007067	mitotic nuclear division
GO:0016567	protein ubiquitination
GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand