Version 5.4
Homo sapiens Protein: KLHDC10
Summary
InnateDB Protein IDBP-41047.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KLHDC10
Protein Name kelch domain containing 10
Synonyms slim;
Species Homo sapiens
Ensembl Protein ENSP00000334140
InnateDB Gene IDBG-41045 (KLHDC10)
Protein Structure
UniProt Annotation
Function Participates in the oxidative stress-induced cell death through MAP3K5 activation. Inhibits PPP5C phosphatase activity on MAP3K5. {ECO:0000269PubMed:23102700}.
Subcellular Localization Nucleus {ECO:0000269PubMed:23102700}. Cytoplasm {ECO:0000269PubMed:23102700}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR006652 Kelch repeat type 1
IPR011498 Kelch repeat type 2
PFAM PF01344
PF07646
PRINTS
PIRSF
SMART SM00612
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6PID8
PhosphoSite PhosphoSite-Q6PID8
TrEMBL C9JRX2
UniProt Splice Variant
Entrez Gene 23008
UniGene Hs.520710
RefSeq NP_055812
HUGO HGNC:22194
OMIM 615152
CCDS CCDS5815
HPRD 17182
IMGT
EMBL AC087071 BC036464 BC044884 CH236950 CH471070 D87454
GenPept AAH36464 AAH44884 BAA13395 EAL24096 EAW83744

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca