InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CHST1

Summary

InnateDB Protein

IDBP-41071.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CHST1

Protein Name

carbohydrate (keratan sulfate Gal-6) sulfotransferase 1

Synonyms

C6ST; GST-1; KS6ST; KSGal6ST; KSST;

Species

Homo sapiens

Ensembl Protein

ENSP00000309270

InnateDB Gene

IDBG-41069 (CHST1)

Protein Structure

UniProt Annotation

Function

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of galactose (Gal) residues of keratan. Has a preference for sulfating keratan sulfate, but it also transfers sulfate to the unsulfated polymer. The sulfotransferase activity on sialyl LacNAc structures is much higher than the corresponding desialylated substrate, and only internal Gal residues are sulfated. May function in the sulfation of sialyl N- acetyllactosamine oligosaccharide chains attached to glycoproteins. Participates in biosynthesis of selectin ligands. Selectin ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation. {ECO:0000269PubMed:10330415, ECO:0000269PubMed:10642612}.

Subcellular Localization

Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed at low level. Expressed in brain and skeletal muscle. Expressed by high endothelial cells (HEVs) and leukocytes. {ECO:0000269PubMed:11310842, ECO:0000269PubMed:9405439}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008146	sulfotransferase activity
GO:0045130	keratan sulfotransferase activity

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0005976	polysaccharide metabolic process
GO:0006012	galactose metabolic process
GO:0006790	sulfur compound metabolic process
GO:0006954	inflammatory response
GO:0018146	keratan sulfate biosynthetic process
GO:0030203	glycosaminoglycan metabolic process
GO:0042339	keratan sulfate metabolic process
GO:0044281	small molecule metabolic process