Version 5.4
Homo sapiens Protein: FOSL2
Summary
InnateDB Protein IDBP-41074.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FOSL2
Protein Name FOS-like antigen 2
Synonyms FRA2;
Species Homo sapiens
Ensembl Protein ENSP00000368939
InnateDB Gene IDBG-41072 (FOSL2)
Protein Structure
UniProt Annotation
Function Controls osteoclast survival and size. As a dimer with JUN, activates LIF transcription. Activates CEBPB transcription in PGE2-activated osteoblasts. {ECO:0000250}.
Subcellular Localization Nucleus.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 27 [view]
Protein-Protein 20 [view]
Protein-DNA 7 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0008219 cell death
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR000837 Fos transforming protein
IPR004827 Basic-leucine zipper domain
IPR008917 Transcription factor, Skn-1-like, DNA-binding domain
PFAM PF00170
PF07716
PRINTS PR00042
PIRSF
SMART SM00338
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P15408
PhosphoSite PhosphoSite-P15408
TrEMBL
UniProt Splice Variant
Entrez Gene 2355
UniGene Hs.696748
RefSeq XP_006712039
HUGO HGNC:3798
OMIM 601575
CCDS
HPRD 03343
IMGT
EMBL AC104695 AK055579 AK302622 AK315415 BC022791 BX647822 CH471053 CR542262 X16706
GenPept AAH22791 AAY14908 BAG37805 BAG51539 BAG63866 CAA34678 CAG47058 EAX00538 EAX00539

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca