InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FOSL2

Summary

InnateDB Protein

IDBP-41080.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FOSL2

Protein Name

FOS-like antigen 2

Synonyms

FRA2;

Species

Homo sapiens

Ensembl Protein

ENSP00000264716

InnateDB Gene

IDBG-41072 (FOSL2)

Protein Structure

UniProt Annotation

Function

Controls osteoclast survival and size. As a dimer with JUN, activates LIF transcription. Activates CEBPB transcription in PGE2-activated osteoblasts. {ECO:0000250}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	27 [view]
Protein-Protein	20 [view]
Protein-DNA	7 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003690	double-stranded DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0007565	female pregnancy
GO:0008219	cell death
GO:0009612	response to mechanical stimulus
GO:0032570	response to progesterone
GO:0032870	cellular response to hormone stimulus
GO:0042493	response to drug
GO:0043278	response to morphine
GO:0048146	positive regulation of fibroblast proliferation
GO:0051412	response to corticosterone
GO:0051591	response to cAMP