InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AP1G1

Summary

InnateDB Protein

IDBP-41182.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AP1G1

Protein Name

adaptor-related protein complex 1, gamma 1 subunit

Synonyms

ADTG; CLAPG1;

Species

Homo sapiens

Ensembl Protein

ENSP00000299980

InnateDB Gene

IDBG-41180 (AP1G1)

Protein Structure

UniProt Annotation

Function

Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.

Subcellular Localization

Golgi apparatus {ECO:0000269PubMed:12773381}. Cytoplasmic vesicle, clathrin- coated vesicle membrane {ECO:0000269PubMed:12773381}; Peripheral membrane protein {ECO:0000269PubMed:12773381}; Cytoplasmic side {ECO:0000269PubMed:12773381}. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.

Disease Associations

Tissue Specificity

Widely expressed.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 49 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	49 [view]
Protein-Protein	49 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005488	binding
GO:0005515	protein binding
GO:0008565	protein transporter activity
GO:0017137	Rab GTPase binding
GO:0019894	kinesin binding
GO:0030742	GTP-dependent protein binding

Biological Process

GO:0006886	intracellular protein transport
GO:0006892	post-Golgi vesicle-mediated transport
GO:0015031	protein transport
GO:0016032	viral process
GO:0016192	vesicle-mediated transport
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0032438	melanosome organization
GO:0035646	endosome to melanosome transport
GO:0043323	positive regulation of natural killer cell degranulation
GO:0045954	positive regulation of natural killer cell mediated cytotoxicity
GO:0050690	regulation of defense response to virus by virus
GO:0061024	membrane organization
GO:0090160	Golgi to lysosome transport

Cellular Component

GO:0000139	Golgi membrane
GO:0005737	cytoplasm
GO:0005765	lysosomal membrane
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0016020	membrane
GO:0030117	membrane coat
GO:0030119	AP-type membrane coat adaptor complex
GO:0030131	clathrin adaptor complex
GO:0030136	clathrin-coated vesicle
GO:0030659	cytoplasmic vesicle membrane
GO:0030665	clathrin-coated vesicle membrane
GO:0032588	trans-Golgi network membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0055037	recycling endosome

Protein Structure and Domains

PDB ID

InterPro

IPR002553 Clathrin/coatomer adaptor, adaptin-like, N-terminal
IPR008152 Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain
IPR008153 Clathrin adaptor, gamma-adaptin, appendage
IPR013041 Coatomer/clathrin adaptor appendage, Ig-like subdomain
IPR016024 Armadillo-type fold
IPR017107 Adaptor protein complex AP-1, gamma subunit

PFAM

PF01602
PF02883

PRINTS

PIRSF

PIRSF037094

SMART

SM00809

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt