Version 5.4
Homo sapiens Protein: EMILIN2
Summary
InnateDB Protein IDBP-412.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EMILIN2
Protein Name elastin microfibril interfacer 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000254528
InnateDB Gene IDBG-410 (EMILIN2)
Protein Structure
UniProt Annotation
Function May be responsible for anchoring smooth muscle cells to elastic fibers, and may be involved not only in the formation of the elastic fiber, but also in the processes that regulate vessel assembly. Has cell adhesive capacity.
Subcellular Localization Secreted, extracellular space, extracellular matrix. Note=Found mainly at the interface between amorphous elastin and microfibrils.
Disease Associations
Tissue Specificity Highest levels are present in fetal heart and adult lung. Intermediate levels in peripheral leukocytes, placenta, and spinal cord and low expression in fetal brain, spleen, thymus, and lung and in adult heart, aorta, testis, bone marrow, small intestine, thymus, lymph node, and appendix.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0030023 extracellular matrix constituent conferring elasticity
Biological Process
GO:0007155 cell adhesion
GO:0008150 biological_process
Cellular Component
GO:0005576 extracellular region
GO:0005578 proteinaceous extracellular matrix
GO:0005581 collagen trimer
Protein Structure and Domains
PDB ID
InterPro IPR001073 Complement C1q protein
IPR008983 Tumour necrosis factor-like domain
IPR011489 EMI domain
PFAM PF00386
PF07546
PRINTS PR00007
PIRSF
SMART SM00110
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BXX0
PhosphoSite PhosphoSite-Q9BXX0
TrEMBL
UniProt Splice Variant
Entrez Gene 84034
UniGene Hs.532815
RefSeq NP_114437
HUGO HGNC:19881
OMIM 608928
CCDS CCDS11828
HPRD 09937
IMGT
EMBL AB026706 AF270513 AK090519 AP000919 AP001011 BC136541 CH471113
GenPept AAI36542 AAK37963 BAB61020 BAC03470 EAX01690

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca