Homo sapiens Protein: DNAH12 | |||||||||
---|---|---|---|---|---|---|---|---|---|
Summary | |||||||||
InnateDB Protein | IDBP-41205.6 | ||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
Gene Symbol | DNAH12 | ||||||||
Protein Name | dynein, axonemal, heavy chain 12 | ||||||||
Synonyms | |||||||||
Species | Homo sapiens | ||||||||
Ensembl Protein | ENSP00000295937 | ||||||||
InnateDB Gene | IDBG-41265 (DNAH12) | ||||||||
Protein Structure | |||||||||
UniProt Annotation | |||||||||
Function | Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity). {ECO:0000250}. | ||||||||
Subcellular Localization | Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000305}. | ||||||||
Disease Associations | |||||||||
Tissue Specificity | |||||||||
Comments | |||||||||
Interactions | |||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
|
||||||||
Gene Ontology | |||||||||
Molecular Function |
|
||||||||
Biological Process |
|
||||||||
Cellular Component |
|
||||||||
Protein Structure and Domains | |||||||||
PDB ID | |||||||||
InterPro |
IPR003593
AAA+ ATPase domain IPR004273 Dynein heavy chain domain IPR011704 ATPase, dynein-related, AAA domain IPR013602 Dynein heavy chain, domain-2 IPR027417 P-loop containing nucleoside triphosphate hydrolase IPR028993 RecG, N-terminal antiparallel four helix bundle |
||||||||
PFAM |
PF03028
PF07728 PF08393 |
||||||||
PRINTS | |||||||||
PIRSF | |||||||||
SMART |
SM00382
|
||||||||
TIGRFAMs | |||||||||
Post-translational Modifications | |||||||||
Modification | |||||||||
Cross-References | |||||||||
SwissProt | Q6ZR08 | ||||||||
PhosphoSite | PhosphoSite-Q6ZR08 | ||||||||
TrEMBL | O15436 | ||||||||
UniProt Splice Variant | |||||||||
Entrez Gene | 201625 | ||||||||
UniGene | Hs.570579 | ||||||||
RefSeq | NP_848599 | ||||||||
HUGO | HGNC:2943 | ||||||||
OMIM | 603340 | ||||||||
CCDS | |||||||||
HPRD | 08281 | ||||||||
IMGT | |||||||||
EMBL | AC092418 AC093928 AC121250 AK097746 AK126276 AK128592 U53532 U83573 | ||||||||
GenPept | AAB09729 AAB82762 BAC05158 BAC86512 BAC87517 | ||||||||