Version 5.4
Homo sapiens Protein: DNAH12
Summary
InnateDB Protein IDBP-41269.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DNAH12
Protein Name dynein, axonemal, heavy chain 12
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000312554
InnateDB Gene IDBG-41265 (DNAH12)
Protein Structure
UniProt Annotation
Function Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003777 microtubule motor activity
GO:0005524 ATP binding
GO:0016887 ATPase activity
Biological Process
GO:0006200 ATP catabolic process
GO:0007018 microtubule-based movement
Cellular Component
GO:0005737 cytoplasm
GO:0005874 microtubule
GO:0005929 cilium
GO:0030286 dynein complex
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6ZR08
PhosphoSite PhosphoSite-Q6ZR08
TrEMBL
UniProt Splice Variant
Entrez Gene 201625
UniGene Hs.570579
RefSeq NP_940966
HUGO HGNC:2943
OMIM 603340
CCDS CCDS33771
HPRD 08281
IMGT
EMBL AC092418 AC093928 AC121250 AK097746 AK126276 AK128592 U53532
GenPept AAB09729 BAC05158 BAC86512 BAC87517

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca