InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SPDYA

Summary

InnateDB Protein

IDBP-41368.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SPDYA

Protein Name

speedy homolog A (Xenopus laevis)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000368898

InnateDB Gene

IDBG-41358 (SPDYA)

Protein Structure

UniProt Annotation

Function

Regulates the G1/S phase transition of the cell cycle by binding and activating CDK1, CDK2 and CDKN1B/KIP1. Can activate CDK2 without promoting CDK2 phosphorylation. Mediates cell survival during the DNA damage process through activation of CDK2. {ECO:0000269PubMed:11980914, ECO:0000269PubMed:12839962, ECO:0000269PubMed:12972555}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:11980914, ECO:0000269PubMed:12972555}.

Disease Associations

Tissue Specificity

Highly expressed in testis. Expressed at a low level in wide range of tissues including bone marrow, brain, heart, kidney, colon, liver, placenta, spleen, skeletal muscle, salivary gland, thyroid gland, thymus, trachea and uterus. Expressed at a slightly higher level in adrenal gland, cerebellum, small intestine, lung, prostate and trachea. Expression is cell cycle-dependent, being restricted to cells in G1/S phase. {ECO:0000269PubMed:11980914, ECO:0000269PubMed:15611625}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0019901	protein kinase binding

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0006974	cellular response to DNA damage stimulus
GO:0007140	male meiosis
GO:0007275	multicellular organismal development
GO:0008284	positive regulation of cell proliferation