InnateDB Protein
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IDBP-41370.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SPDYA
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Protein Name
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speedy homolog A (Xenopus laevis)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000335628
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InnateDB Gene
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IDBG-41358 (SPDYA)
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Protein Structure
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Function |
Regulates the G1/S phase transition of the cell cycle by binding and activating CDK1, CDK2 and CDKN1B/KIP1. Can activate CDK2 without promoting CDK2 phosphorylation. Mediates cell survival during the DNA damage process through activation of CDK2. {ECO:0000269PubMed:11980914, ECO:0000269PubMed:12839962, ECO:0000269PubMed:12972555}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:11980914, ECO:0000269PubMed:12972555}.
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Disease Associations |
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Tissue Specificity |
Highly expressed in testis. Expressed at a low level in wide range of tissues including bone marrow, brain, heart, kidney, colon, liver, placenta, spleen, skeletal muscle, salivary gland, thyroid gland, thymus, trachea and uterus. Expressed at a slightly higher level in adrenal gland, cerebellum, small intestine, lung, prostate and trachea. Expression is cell cycle-dependent, being restricted to cells in G1/S phase. {ECO:0000269PubMed:11980914, ECO:0000269PubMed:15611625}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
9
[view]
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Protein-Protein |
9
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0019901
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protein kinase binding
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Biological Process |
GO:0000082
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G1/S transition of mitotic cell cycle
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GO:0006974
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cellular response to DNA damage stimulus
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GO:0007140
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male meiosis
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GO:0007275
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multicellular organismal development
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GO:0008284
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positive regulation of cell proliferation
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GO:0045737
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positive regulation of cyclin-dependent protein serine/threonine kinase activity
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Cellular Component |
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PDB ID |
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InterPro |
IPR020984
Cell cycle regulatory protein, Spy1
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PFAM |
PF11357
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q5MJ70
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PhosphoSite |
PhosphoSite-Q5MJ70
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TrEMBL |
Q53R02
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UniProt Splice Variant |
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Entrez Gene |
245711
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UniGene |
Hs.629537
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RefSeq |
NP_877433
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HUGO |
HGNC:30613
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OMIM |
614029
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CCDS |
CCDS1767
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HPRD |
18095
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IMGT |
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EMBL |
AC097720
AC097724
AY820303
AY820304
BC093005
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GenPept |
AAH93005
AAW30394
AAW30395
AAY24014
AAY24125
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