InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TRMT61B

Summary

InnateDB Protein

IDBP-41623.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRMT61B

Protein Name

tRNA methyltransferase 61 homolog B (S. cerevisiae)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000302801

InnateDB Gene

IDBG-41619 (TRMT61B)

Protein Structure

UniProt Annotation

Function

Methyltransferase that catalyzes the formation of N(1)- methyladenine at position 58 (m1A58) in various tRNAs in mitochondrion, including tRNA(Leu) (decephering codons UUA or UUG), tRNA(Lys) and tRNA(Ser) (decephering codons UCA, UCU, UCG or UCC). {ECO:0000269PubMed:23097428}.

Subcellular Localization

Mitochondrion {ECO:0000269PubMed:23097428}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Experimentally validated
Total	7 [view]
Protein-Protein	6 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004719	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity
GO:0005515	protein binding
GO:0016429	tRNA (adenine-N1-)-methyltransferase activity

Biological Process

GO:0006464	cellular protein modification process
GO:0030488	tRNA methylation
GO:0051260	protein homooligomerization
GO:0070901	mitochondrial tRNA methylation

Cellular Component

GO:0005739	mitochondrion
GO:0031515	tRNA (m1A) methyltransferase complex

Protein Structure and Domains

PDB ID

InterPro

IPR000682 Protein-L-isoaspartate(D-aspartate) O-methyltransferase
IPR014816 tRNA (1-methyladenosine) methyltransferase catalytic subunit Gcd14
IPR029063 S-adenosyl-L-methionine-dependent methyltransferase-like

PFAM

PF01135
PF08704

PRINTS

PIRSF

PIRSF017269

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9BVS5