InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GPC5

Summary

InnateDB Protein

IDBP-41695.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GPC5

Protein Name

glypican 5

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000366267

InnateDB Gene

IDBG-41693 (GPC5)

Protein Structure

UniProt Annotation

Function

Cell surface proteoglycan that bears heparan sulfate. {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}; Extracellular side {ECO:0000250}.Secreted glypican-5: Secreted, extracellular space {ECO:0000250}.

Disease Associations

Tissue Specificity

In adult, primarily expressed in the brain. Also detected in fetal brain, lung and liver. {ECO:0000269PubMed:9070915, ECO:0000269PubMed:9331333}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0043395	heparan sulfate proteoglycan binding

Biological Process

GO:0001523	retinoid metabolic process
GO:0005975	carbohydrate metabolic process
GO:0006024	glycosaminoglycan biosynthetic process
GO:0006027	glycosaminoglycan catabolic process
GO:0007603	phototransduction, visible light
GO:0030203	glycosaminoglycan metabolic process
GO:0030204	chondroitin sulfate metabolic process
GO:0044281	small molecule metabolic process

Cellular Component

GO:0005578	proteinaceous extracellular matrix
GO:0005615	extracellular space
GO:0005796	Golgi lumen
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0031225	anchored component of membrane
GO:0043202	lysosomal lumen