Version 5.4
Homo sapiens Protein: HARBI1
Summary
InnateDB Protein IDBP-41835.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HARBI1
Protein Name harbinger transposase derived 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000317743
InnateDB Gene IDBG-41833 (HARBI1)
Protein Structure
UniProt Annotation
Function Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activity. {ECO:0000269PubMed:15169610, ECO:0000269PubMed:18339812, ECO:0000305}.
Subcellular Localization Nucleus {ECO:0000269PubMed:18339812}. Cytoplasm {ECO:0000269PubMed:18339812}. Note=Interaction with NAIF1 promotes translocation to the nucleus.
Disease Associations
Tissue Specificity Detected in brain, eye, nerve tissue, kidney and lung. {ECO:0000269PubMed:15169610}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004518 nuclease activity
GO:0016788 hydrolase activity, acting on ester bonds
GO:0046872 metal ion binding
Biological Process
GO:0090305 nucleic acid phosphodiester bond hydrolysis
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005813 centrosome
Protein Structure and Domains
PDB ID
InterPro IPR006912 Harbinger transposase-derived protein, plant
PFAM PF04827
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96MB7
PhosphoSite PhosphoSite-Q96MB7
TrEMBL E9PQI1
UniProt Splice Variant
Entrez Gene 283254
UniGene Hs.714463
RefSeq NP_776172
HUGO HGNC:26522
OMIM 615086
CCDS CCDS7920
HPRD 08728
IMGT
EMBL AC127035 AK057237 BC036925 CH471064
GenPept AAH36925 BAB71391 EAW67992 EAW67993 EAW67994

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca