InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SFRP2

Summary

InnateDB Protein

IDBP-41864.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SFRP2

Protein Name

secreted frizzled-related protein 2

Synonyms

FRP-2; SARP1; SDF-5;

Species

Homo sapiens

Ensembl Protein

ENSP00000274063

InnateDB Gene

IDBG-41862 (SFRP2)

Protein Structure

UniProt Annotation

Function

Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP2 may be important for eye retinal development and for myogenesis.

Subcellular Localization

Secreted {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in adipose tissue, heart, brain, skeletal muscle, pancreas, thymus, prostate, testis, ovary, small intestine and colon. Highest levels in adipose tissue, small intestine and colon. {ECO:0000269PubMed:9391078, ECO:0000269PubMed:9642118}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001968	fibronectin binding
GO:0005178	integrin binding
GO:0005515	protein binding
GO:0010577	metalloenzyme activator activity
GO:0017147	Wnt-protein binding
GO:0030165	PDZ domain binding
GO:0042813	Wnt-activated receptor activity
GO:0048018	receptor agonist activity
GO:0061133	endopeptidase activator activity

Biological Process

GO:0001569	patterning of blood vessels
GO:0001756	somitogenesis
GO:0001843	neural tube closure
GO:0001944	vasculature development
GO:0002063	chondrocyte development
GO:0003151	outflow tract morphogenesis
GO:0003214	cardiac left ventricle morphogenesis
GO:0006915	apoptotic process
GO:0007267	cell-cell signaling
GO:0007420	brain development
GO:0007584	response to nutrient
GO:0008284	positive regulation of cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0008406	gonad development
GO:0008584	male gonad development
GO:0009952	anterior/posterior pattern specification
GO:0010629	negative regulation of gene expression
GO:0010667	negative regulation of cardiac muscle cell apoptotic process
GO:0010719	negative regulation of epithelial to mesenchymal transition
GO:0010950	positive regulation of endopeptidase activity
GO:0021915	neural tube development
GO:0030111	regulation of Wnt signaling pathway
GO:0030178	negative regulation of Wnt signaling pathway
GO:0030199	collagen fibril organization
GO:0030307	positive regulation of cell growth
GO:0030308	negative regulation of cell growth
GO:0030336	negative regulation of cell migration
GO:0030514	negative regulation of BMP signaling pathway
GO:0031668	cellular response to extracellular stimulus
GO:0033138	positive regulation of peptidyl-serine phosphorylation
GO:0033630	positive regulation of cell adhesion mediated by integrin
GO:0035413	positive regulation of catenin import into nucleus
GO:0036342	post-anal tail morphogenesis
GO:0042127	regulation of cell proliferation
GO:0042493	response to drug
GO:0042662	negative regulation of mesodermal cell fate specification
GO:0042733	embryonic digit morphogenesis
GO:0042981	regulation of apoptotic process
GO:0043065	positive regulation of apoptotic process
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043508	negative regulation of JUN kinase activity
GO:0045600	positive regulation of fat cell differentiation
GO:0045669	positive regulation of osteoblast differentiation
GO:0045766	positive regulation of angiogenesis
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046546	development of primary male sexual characteristics
GO:0048546	digestive tract morphogenesis
GO:0050680	negative regulation of epithelial cell proliferation
GO:0050732	negative regulation of peptidyl-tyrosine phosphorylation
GO:0051216	cartilage development
GO:0060028	convergent extension involved in axis elongation
GO:0060349	bone morphogenesis
GO:0061056	sclerotome development
GO:0061185	negative regulation of dermatome development
GO:0071425	hematopoietic stem cell proliferation
GO:0071481	cellular response to X-ray
GO:0090090	negative regulation of canonical Wnt signaling pathway
GO:0090175	regulation of establishment of planar polarity
GO:0090179	planar cell polarity pathway involved in neural tube closure
GO:0090244	Wnt signaling pathway involved in somitogenesis
GO:0090263	positive regulation of canonical Wnt signaling pathway
GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902230	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO:2000035	regulation of stem cell division
GO:2000041	negative regulation of planar cell polarity pathway involved in axis elongation

Cellular Component

GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0031012	extracellular matrix

Protein Structure and Domains

PDB ID

InterPro

IPR001134 Netrin domain
IPR008993 Tissue inhibitor of metalloproteinases-like, OB-fold
IPR018933 Netrin module, non-TIMP type
IPR020067 Frizzled domain

PFAM

PF01759
PF01392

PRINTS

PIRSF

SMART

SM00643
SM00063

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q96HF1