Version 5.4
Homo sapiens Protein: TMC2
Summary
InnateDB Protein IDBP-41974.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TMC2
Protein Name transmembrane channel-like 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000351732
InnateDB Gene IDBG-41972 (TMC2)
Protein Structure
UniProt Annotation
Function Probable ion channel required for the normal function of cochlear hair cells. {ECO:0000269PubMed:11850618}.
Subcellular Localization Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Detected in fetal cochlea.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005245 voltage-gated calcium channel activity
Biological Process
GO:0006811 ion transport
GO:0050910 detection of mechanical stimulus involved in sensory perception of sound
GO:0060005 vestibular reflex
GO:0070588 calcium ion transmembrane transport
Cellular Component
GO:0016021 integral component of membrane
GO:0032426 stereocilium bundle tip
Protein Structure and Domains
PDB ID
InterPro IPR012496 TMC
PFAM PF07810
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8TDI7
PhosphoSite PhosphoSite-Q8TDI7
TrEMBL
UniProt Splice Variant
Entrez Gene 117532
UniGene
RefSeq NP_542789
HUGO HGNC:16527
OMIM 606707
CCDS CCDS13029
HPRD 09463
IMGT
EMBL AF417580 AK094789 AK127751 AL049712 AY358613
GenPept AAL86401 AAQ88976 BAC04423 CAI22420

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca