InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TSHZ3

Summary

InnateDB Protein

IDBP-42069.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TSHZ3

Protein Name

teashirt zinc finger homeobox 3

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000240587

InnateDB Gene

IDBG-42067 (TSHZ3)

Protein Structure

UniProt Annotation

Function

Transcriptional regulator involved in developmental processes. Function in association with APBB1, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. TSHZ3-mediated transcription repression involves the recruitment of histone deacetylases HDAC1 and HDAC2. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s). Regulates the development of neurons involved in both respiratory rhythm and airflow control. Promotes maintenance of nucleus ambiguus (nA) motoneurons, which govern upper airway function, and establishes a respiratory rhythm generator (RRG) activity compatible with survival at birth. Involved in the differentiation of the proximal uretic smooth muscle cells during developmental processes. Involved in the up- regulation of myocardin, that directs the expression of smooth muscle cells in the proximal ureter. {ECO:0000269PubMed:19343227}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00108, ECO:0000269PubMed:19343227}. Cell projection, growth cone {ECO:0000250}. Note=Colocalizes with APBB1 in axonal growth cone (By similarity). Colocalizes with APBB1 in the nucleus. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in brain; strongly reduced in post- mortem elderly subjects with Alzheimer disease. {ECO:0000269PubMed:18776146, ECO:0000269PubMed:19343227}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0001656	metanephros development
GO:0001657	ureteric bud development
GO:0001701	in utero embryonic development
GO:0002087	regulation of respiratory gaseous exchange by neurological system process
GO:0006351	transcription, DNA-templated
GO:0030324	lung development
GO:0045892	negative regulation of transcription, DNA-templated
GO:0048745	smooth muscle tissue development
GO:0050881	musculoskeletal movement
GO:0050975	sensory perception of touch
GO:0051152	positive regulation of smooth muscle cell differentiation
GO:0060993	kidney morphogenesis
GO:0072105	ureteric peristalsis
GO:0072193	ureter smooth muscle cell differentiation
GO:0072195	kidney smooth muscle cell differentiation