Version 5.4
Homo sapiens Protein: WDR59
Summary
InnateDB Protein IDBP-42209.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol WDR59
Protein Name WD repeat domain 59
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000262144
InnateDB Gene IDBG-42207 (WDR59)
Protein Structure
UniProt Annotation
Function As a component of the GATOR2 complex, inhibits GATOR1 complex, an inhibitor of the amino acid-sensing branch of the TORC1 pathway.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0008150 biological_process
Cellular Component
GO:0005575 cellular_component
Protein Structure and Domains
PDB ID
InterPro IPR001680 WD40 repeat
IPR006575 RWD domain
IPR016135 Ubiquitin-conjugating enzyme/RWD-like
IPR017986 WD40-repeat-containing domain
PFAM PF00400
PF05773
PRINTS
PIRSF
SMART SM00320
SM00591
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6PJI9
PhosphoSite PhosphoSite-Q6PJI9
TrEMBL H3BUE9
UniProt Splice Variant
Entrez Gene 79726
UniGene Hs.280951
RefSeq NP_085058
HUGO HGNC:25706
OMIM
CCDS CCDS32488
HPRD 13351
IMGT
EMBL AB067510 AC009132 AC092383 AF370390 AK022332 AK091316 BC004519 BC014887
GenPept AAH04519 AAH14887 AAQ15226 BAB14015 BAB67816 BAG52335

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca