InnateDB Protein
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IDBP-42219.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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AKR1B10
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Protein Name
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aldo-keto reductase family 1, member B10 (aldose reductase)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000352584
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InnateDB Gene
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IDBG-42217 (AKR1B10)
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Protein Structure
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Function |
Acts as all-trans-retinaldehyde reductase. Can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). May be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs. {ECO:0000269PubMed:18087047}.
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Subcellular Localization |
Lysosome {ECO:0000269PubMed:21585341}. Secreted {ECO:0000269PubMed:21585341}. Note=Secreted through a lysosome-mediated non-classical pathway.
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Disease Associations |
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Tissue Specificity |
Found in many tissues. Highly expressed in small intestine, colon and adrenal gland.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
3
[view]
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Protein-Protein |
3
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR020471
Aldo/keto reductase subgroup
IPR023210
NADP-dependent oxidoreductase domain
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PFAM |
PF00248
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PRINTS |
PR00069
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PIRSF |
PIRSF000097
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
O60218
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PhosphoSite |
PhosphoSite-O60218
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
57016
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UniGene |
Hs.116724
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RefSeq |
NP_064695
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HUGO |
HGNC:382
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OMIM |
604707
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CCDS |
CCDS5832
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HPRD |
05271
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IMGT |
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EMBL |
AC078847
AF044961
AF052577
AF524864
BC008837
BT006794
CH236950
CH471070
CR541801
U37100
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GenPept |
AAC15671
AAC17469
AAC36465
AAH08837
AAO13380
AAP35440
CAG46600
EAL24069
EAW83816
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