InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ACOX2

Summary

InnateDB Protein

IDBP-42299.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ACOX2

Protein Name

acyl-CoA oxidase 2, branched chain

Synonyms

BCOX; BRCACOX; BRCOX; THCCox;

Species

Homo sapiens

Ensembl Protein

ENSP00000307697

InnateDB Gene

IDBG-42297 (ACOX2)

Protein Structure

UniProt Annotation

Function

Oxidizes the CoA esters of the bile acid intermediates di- and tri-hydroxycholestanoic acids.

Subcellular Localization

Peroxisome.

Disease Associations

Tissue Specificity

Present in all tissues tested: heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Most abundant in heart, liver and kidney.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003995	acyl-CoA dehydrogenase activity
GO:0003997	acyl-CoA oxidase activity
GO:0005102	receptor binding
GO:0016402	pristanoyl-CoA oxidase activity
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors
GO:0033791	3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity
GO:0050660	flavin adenine dinucleotide binding

Biological Process

GO:0006631	fatty acid metabolic process
GO:0006635	fatty acid beta-oxidation
GO:0006699	bile acid biosynthetic process
GO:0008152	metabolic process
GO:0008206	bile acid metabolic process
GO:0033540	fatty acid beta-oxidation using acyl-CoA oxidase
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005777	peroxisome
GO:0005782	peroxisomal matrix

Protein Structure and Domains

PDB ID

InterPro

IPR002655 Acyl-CoA oxidase, C-terminal
IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain
IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal
IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain
IPR012258 Acyl-CoA oxidase

PFAM

PF01756
PF02770
PF00441

PRINTS

PIRSF

PIRSF000168

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q99424