InnateDB Protein
|
IDBP-4230.5
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
RNF152
|
Protein Name
|
ring finger protein 152
|
Synonyms
|
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000316628
|
InnateDB Gene
|
IDBG-4228 (RNF152)
|
Protein Structure
|
|
Function |
E3 ubiquitin-protein ligase mediating 'Lys-48'-linked polyubiquitination of target proteins and their subsequent targeting to the proteasome for degradation. Induces apoptosis when overexpressed. {ECO:0000269PubMed:21203937}.
|
Subcellular Localization |
Lysosome membrane {ECO:0000305PubMed:21203937}; Single-pass membrane protein {ECO:0000305PubMed:21203937}.
|
Disease Associations |
|
Tissue Specificity |
Widely expressed. {ECO:0000269PubMed:21203937}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
4
[view]
|
Protein-Protein |
4
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR001841
Zinc finger, RING-type
IPR018957
Zinc finger, C3HC4 RING-type
|
PFAM |
PF13639
PF14634
PF00097
|
PRINTS |
|
PIRSF |
|
SMART |
SM00184
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q8N8N0
|
PhosphoSite |
PhosphoSite-Q8N8N0
|
TrEMBL |
K7EMG3
|
UniProt Splice Variant |
|
Entrez Gene |
220441
|
UniGene |
Hs.667457
|
RefSeq |
NP_775828
|
HUGO |
HGNC:26811
|
OMIM |
|
CCDS |
CCDS11978
|
HPRD |
11514
|
IMGT |
|
EMBL |
AC105094
AC105183
AK096495
AK122758
BC094004
BC111956
|
GenPept |
AAH94004
AAI11957
BAC04805
BAG53711
|
|
|