InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IDH3B

Summary

InnateDB Protein

IDBP-42311.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IDH3B

Protein Name

isocitrate dehydrogenase 3 (NAD+) beta

Synonyms

H-IDHB; RP46;

Species

Homo sapiens

Ensembl Protein

ENSP00000370223

InnateDB Gene

IDBG-42307 (IDH3B)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Mitochondrion.

Disease Associations

Retinitis pigmentosa 46 (RP46) [MIM:612572]: A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. {ECO:0000269PubMed:18806796}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	9 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004449	isocitrate dehydrogenase (NAD+) activity
GO:0009055	electron carrier activity
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0051287	NAD binding

Biological Process

GO:0006099	tricarboxylic acid cycle
GO:0006102	isocitrate metabolic process
GO:0006103	2-oxoglutarate metabolic process
GO:0006734	NADH metabolic process
GO:0044237	cellular metabolic process
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process