InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LDHD

Summary

InnateDB Protein

IDBP-42334.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LDHD

Protein Name

lactate dehydrogenase D

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000300051

InnateDB Gene

IDBG-42332 (LDHD)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Mitochondrion {ECO:0000250UniProtKB:Q7TNG8}.

Disease Associations

Tissue Specificity

Expressed moderately in heart and liver and at lower levels in skeletal muscle and kidney. {ECO:0000269PubMed:12127981}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004458	D-lactate dehydrogenase (cytochrome) activity
GO:0005515	protein binding
GO:0008762	UDP-N-acetylmuramate dehydrogenase activity
GO:0016491	oxidoreductase activity
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors
GO:0050660	flavin adenine dinucleotide binding

Biological Process

GO:0055114

oxidation-reduction process

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane

Protein Structure and Domains

PDB ID

InterPro

IPR004113 FAD-linked oxidase, C-terminal
IPR006094 FAD linked oxidase, N-terminal
IPR016164 FAD-linked oxidase-like, C-terminal
IPR016166 FAD-binding, type 2

PFAM

PF02913
PF01565

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q86WU2

PhosphoSite