InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GUCY1B3

Summary

InnateDB Protein

IDBP-42430.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GUCY1B3

Protein Name

guanylate cyclase 1, soluble, beta 3

Synonyms

GC-S-beta-1; GC-SB3; GUC1B3; GUCB3; GUCSB3; GUCY1B1;

Species

Homo sapiens

Ensembl Protein

ENSP00000264424

InnateDB Gene

IDBG-42428 (GUCY1B3)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.

Experimentally validated
Total	12 [view]
Protein-Protein	9 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004383	guanylate cyclase activity
GO:0004872	receptor activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0016849	phosphorus-oxygen lyase activity
GO:0020037	heme binding
GO:0043167	ion binding
GO:0046872	metal ion binding
GO:0046982	protein heterodimerization activity
GO:0051879	Hsp90 protein binding

Biological Process

GO:0006182	cGMP biosynthetic process
GO:0007263	nitric oxide mediated signal transduction
GO:0007596	blood coagulation
GO:0008015	blood circulation
GO:0009190	cyclic nucleotide biosynthetic process
GO:0035556	intracellular signal transduction

Cellular Component

GO:0005737	cytoplasm
GO:0008074	guanylate cyclase complex, soluble
GO:0043231	intracellular membrane-bounded organelle
GO:0043234	protein complex

Protein Structure and Domains

PDB ID

InterPro

IPR001054 Adenylyl cyclase class-3/4/guanylyl cyclase
IPR011644 Heme-NO binding
IPR011645 Haem NO binding associated
IPR024096 NO signalling/Golgi transport ligand-binding domain
IPR029787 Nucleotide cyclase

PFAM

PF00211
PF07700
PF07701

PRINTS

PIRSF

SMART

SM00044

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q02153