InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: G2E3

Summary

InnateDB Protein

IDBP-4251.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

G2E3

Protein Name

G2/M-phase specific E3 ubiquitin protein ligase

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000206595

InnateDB Gene

IDBG-4249 (G2E3)

Protein Structure

UniProt Annotation

Function

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Essential in early embryonic development to prevent apoptotic death. {ECO:0000269PubMed:18511420}.

Subcellular Localization

Nucleus, nucleolus {ECO:0000269PubMed:17239372}. Cytoplasm {ECO:0000269PubMed:17239372}. Note=Shuttles between the nucleus and the cytoplasm. In the nucleus, delocalizes from the nucleolus to the nucleoplasm in response to DNA damage.

Disease Associations

Tissue Specificity

Predominantly expressed in brain, liver, kidney, testes and ovary. {ECO:0000269PubMed:10718198}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity

Biological Process

GO:0000209	protein polyubiquitination
GO:0001824	blastocyst development
GO:0006915	apoptotic process
GO:2001243	negative regulation of intrinsic apoptotic signaling pathway