InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: INHBC

Summary

InnateDB Protein

IDBP-42551.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

INHBC

Protein Name

inhibin, beta C

Synonyms

IHBC;

Species

Homo sapiens

Ensembl Protein

ENSP00000308716

InnateDB Gene

IDBG-42549 (INHBC)

Protein Structure

UniProt Annotation

Function

Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.

Subcellular Localization

Secreted {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in benign prostatic hyperplasia. {ECO:0000269PubMed:9428386}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005160	transforming growth factor beta receptor binding
GO:0005179	hormone activity
GO:0008083	growth factor activity

Biological Process

GO:0040007

growth

Cellular Component

GO:0005576	extracellular region
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001111 Transforming growth factor-beta, N-terminal
IPR001318 Inhibin, beta C subunit
IPR001839 Transforming growth factor-beta, C-terminal
IPR029034 Cystine-knot cytokine

PFAM

PF00688
PF00019

PRINTS

PR00672

PIRSF

SMART

SM00204

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt